DoxyPEP | MESMAC

We use necessary cookies to make our site work. We'd like to set additional cookies to understand site usage, make site improvements and to remember your settings. We also use cookies set by other sites to help deliver content from their services. Read our cookie statement.

Skip to content
Search Language
Book a test
Menu

Page

DoxyPEP

DoxyPEP is a dose of the antibiotic doxycycline taken after sex to help prevent some STIs. Find out what it is and whether it might be a good choice for you.

DoxyPEP is a new tool we can use to look after our sexual health. Here’s some information for you decide whether it might be a good choice for you.

What is DoxyPEP?
  • It is a pill with an antibiotic called doxycycline
  • You take it after you have sex without a condom
  • It can help stop you getting syphilis and chlamydia
  • It is not always a replacement for condoms. It is an extra choice to help stop you from developing syphilis and chlamydia only.
Who is DoxyPEP for?

DoxyPEP is recommended for:

  • Gay men, bisexual men and other men who have sex with men
  • Trans women
  • Especially if you are at a higher chance of getting syphilis

You might have a higher chance if:

  • You have had an STI like syphilis or chlamydia in the last year
  • You have had more than one new partner in the last few months
  • You have sex in groups or use drugs for sex (chemsex)
  • Having sex is part of your job
How do I take DoxyPEP?
  • How much? Take 2 pills (2x 100mg) at the same time
  • When? Take it within 3 days (72 hours) after sex without a condom. Sooner is better!
  • How often? Never take more than one dose (2 pills) in a single day

For example, if you have sex on Friday and Saturday, you can take one dose on Sunday to cover both days

The good thing DoxyPEP
  • It works very well. It can stop about 8 out of 10 syphilis and chlamydia infections
  • It can make you feel less worried about getting STIs
  • It gives you more control over your health
Important things to know
  • It doesn't work for everything. It doesn't stop HIV. You still need PrEP or condoms to prevent HIV transmission if your HIV positive partner is not on effective treatment
  • It is not effective at preventing other STIs
  • Testing is still important! You should still get tested for STIs regularly. DoxyPEP is not 100% so you could still get an infection
  • Side effects: some people get a sore stomach, feel sick or gete sunburned more easily. This is usually mild.

For more information and to discuss DoxyPEP contact your local MESMAC office or simply make an appointment at your nearest sexual health clinic.

To viw the latest DoxyPEP guidance from the British Association for Sexual Health and HIV, click here.